One of the duties mentioned in the Holy Quran - after the command to worship God - is kindness to parents.  Therefore, in the Qur'an and hadiths, there is a lot of emphasis on respecting the rights of parents and kindness to them. 
Imam Sadegh (AS) says:
"Harassing one's parents is one of the great sins; "For God has made
the one who has ...
in islam the rendering of one's good deeds invalid cannot be based on mere opinion or analogy. the only authentic reports of a persons deeds being invalidated is of only by major shirk, ascribing partners to Allah azzawajjal. there is no evidence to prove that disrespecting parents will invalidate all the good deeds.
but it is of no doubt ...