A large part of the Quran is quite clear and it can be understood quite easily even in a translation. For the rest, a Tafsir is a good help. If now, renown scholars differ on the meaning of an Aya, we are in those passages that are really not easy to understand.
There are two cases to discern:
If the interpretation of the passage is something important for us, but not a subject of legal importance, we have to study the arguments of both scholars, and other scholars after them, and finally, it is our own decision that decides for ourselves.
In the case that the subject concerns Sharia, the decision should be given to a contemporary scholar for Fatwa.
In the third case, if it is not really important in our lives, we can simply acknowledge that the passage can be understood in different ways without a decision which one is more likely.